Home » News » UK Makes Gene Therapy Breakthrough for Blindness

UK Makes Gene Therapy Breakthrough for Blindness

by Bryant Jordan on March 31, 2014

BlindnessThe Department of Veterans Affairs says it currently has more than 150,000 patients who are legally blind because of age-related illnesses, and the number will grow considerably in coming years as Korean and Vietnam war vets continue to hit their 70s and beyond.

But some breakthrough research out of Great Britain could change all that.

At Oxford Eye Hospital the vision of six male patients with a degenerative eye disease was improved after doctors inserted a healthy copy of a defective gene into an engineered virus that entered the retina and actually replaced the sick gene.

Dr. Robert MacLaren of the University of Oxford and a consultant surgeon at the eye hospital said some vision was restored even for two men whose condition was advanced.

“In truth, we did not expect to see such dramatic improvements in visual acuity and so we contacted both patients’ home opticians to get current and historical data on their vision in former years, long before the gene therapy trial started,” MacLaren said in a university news release. “These readings confirmed exactly what we had seen in our study and provided an independent verification.”

In the test, the men were treated for choroideremia, which affects about one in every 50,000 people, Oxford University said in a news release. But MacLaren said in the university release that the science will extend to other conditions.

“This has huge implications for anyone with a genetic retinal disease such as age-related macular degeneration or retinitis pigmentosa, because it has for the first time shown that gene therapy can be applied safely before the onset of vision loss,” he said.

Total VA funding for its services for blind and vision impaired vets has grown from $94 million in 2007 to $142 million last year, according to Mark Cornell, national president for the Blind Veterans Association. Cornell, who testified earlier this month before Congress, pointed out that in addition to the 157,000 legally blind veterans, the VA estimates there are about 1.1 million “low vision impaired” veterans – that is, with 20/70 vision or worse.

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{ 16 comments… read them below or add one }

Stephen Russell March 31, 2014 at 11:39 am

Lisc for use worldwide, awesome, mass replicate procedures.


SJE March 31, 2014 at 12:14 pm

This has immediate application to the specific genetic-based retinal blindness, midterm for other genetic-based blindness, and probably age-related. For those vets and others who lost their sight to combat injury etc, they might be able to develop a viral-delivered method that minimizes damage, and aids healing, but thats a long way off.


orly? March 31, 2014 at 6:19 pm

Damned socialist healthcare.


hibeam March 31, 2014 at 7:57 pm

Socialism works great. Ask the former USSR. A blind dog finds a bone and you want to rewrite history.


SJE March 31, 2014 at 9:14 pm

The UK has socialist healthcare, and developed this technology.


Beno April 1, 2014 at 4:25 am

We have, but as a univercity research project this was almost certainly privatly funded. The NHS doesnt necessarily govern all things health over here.



SJE April 2, 2014 at 12:22 pm

Most early stage research funds come from the government. The notable exception is the Wellcome Trust.


elizzar April 2, 2014 at 3:33 pm

As SJE wrote, most of the research is either paid for by the UK government from taxpayer money or by charities. A small part is paid for by private companies, who have specific goals and desires and are very controlling (as well as aiming for a profit in the long term). Our major problem in the UK is translating the taxpayer-funded research into marketable products / licenses ourselves without being ripped-off or some company making a killing on it.


hibeam April 1, 2014 at 9:02 am

Socialism is like an old fat boxer who never faces an opponent. The Socialist will constantly tell you what a great champion he is. Compared to what?


Charles April 1, 2014 at 9:08 am

When it comes to healthcare for the general population, the US frankly stinks, and pays far more than any other nation. Britain is overall, vastly superior to the US in this respect, and Canada is even better.

Healthcare for profit is and has been proven to be against the public interest, and a tremendous waste of money.


hibeam April 1, 2014 at 9:26 am

Is Cuba better? According to you it should be. Why are American schools so horrible? The government runs education. How is Solyndra doing? Does Britain have 30 million poor illegal Mexicans using it's emergency rooms for free? No? In America there is an industry built around suing doctors every five minutes. Socialism only works when their is no competition.

SJE April 2, 2014 at 12:24 pm

The US has the best healthcare, if you can afford to pay out of pocket. For the 99%, it ranks as the least efficient and least effective in the world.

Hunter76 April 1, 2014 at 9:05 am

Ok, choroideremia affects 1 in 50,000, not exactly a major disease. And why is this a defense matter? Do veterans have a special entitlement to treatment of this age-related condition?


Psalamndr April 12, 2014 at 7:41 pm

Wow talk about the insanity of this world. We have an article about something that will help people who are going blind with a method that can be modified for different genetic disorders, and some are seeming to say that it might not be a good thing, depending on where the money came from.
When did it become more important to be right than to just do the next right thing?


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